The vector mosquito bites
contaminated person and ingests
and male gametocytes of parasite.
Within the insect the gametocytes
differentiate into and
fecundation occurs, forming .
Each plasmodium zygote by
(sporogony) generates numerous
infective that migrate to the
glands of the mosquito.
the mosquito bites a the
sporozoites enter the circulation
and when in liver they undergo the
asexual reproduction (tissue
schizogony), several
merozoites into the . The
merozoites infect red cells where
the second reproduction of the
cycle () and the
production of other parasites
occur; some these parasites
differentiate into . The red
blood cells break (hemolysis), the
parasites released in the blood
the cycle can restart.